Brassybra is manufactured under very strict conditions, we use a medical grade, hypoallergenic adhesive that provides a very strong hold. In the unlikely event Brassybra causes skin irritation there may be several reasons for this, for example; incorrect use, wearing longer than recommended, using it consecutive days, removing without oil, pulling your skin too much in application, or it's possible you could be allergic or sensitive to the adhesive. We provide a test strip in each box so that you can try the adhesive before use. We do not recommend use on very sensitive skin. If you experience a rash, blemishes, itching or similar symptoms, stop using immediately and contact customer service.